LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.

@article{Burguire2005LosAAK,
  title={LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.},
  author={Adeline Burgui{\`e}re and Paul Hitchen and Lynn George Dover and Laurent Kremer and Malin Ridell and David C. Alexander and Jun Yong Liu and Howard R. Morris and David E. Minnikin and Anne Dell and Gurdyal S Besra},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 51},
  pages={42124-33}
}
Members of the genus Mycobacterium are characterized by cell envelopes rich in unusual free lipids, interacting with a covalently anchored mycolyl-arabinogalactan matrix. Previous studies have shown that Mycobacterium marinum produces large amounts of a diacylglycosylphenolphthiocerol, "phenolic" glycolipid. When cultivated on liquid Sauton medium, traces of a polar lipooligosaccharide (LOS) glycolipid antigen were also previously indicated. In this study, it was found that growth of the type… CONTINUE READING