Lorcainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy.

  title={Lorcainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy.},
  author={C e Eiriksson and Rex N. Brogden},
  volume={27 4},
Lorcainide is a type I antiarrhythmic drug of the local anesthetic type. It can be given either intravenously or orally, and its pharmacokinetic properties allow relatively long (12 hours) dosing intervals with oral administration. A slowly eliminated metabolite, norlorcainide, probably contributes to the effects of orally administered lorcainide in chronically treated patients. In mainly short term studies, lorcainide has been shown to suppress ventricular ectopy in about 80% of patients… CONTINUE READING


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 45 references

Arrhythmogenic effect of toxic concentrations of the antiarrh ythmic drug lorcain ide on the isolated canine ventr icle

  • J. Senges., I. Rizos, J. Brachmann., G. Tian-Li., W. Lengfelder, W. Kubler.
  • Jour - nal of the American College of Cardio logy
  • 1983

Lorcainide : An oral and intravenous antiarrhythmic agent with long duration of action

  • A. A. Almotrefi, J. B. E. Baker
  • 1983

availability and saturation of the presystemic metabolism of oral lorcainide therapy initiated in three different dose regimens

  • W. Bar.F., J. Farre, D. Ross., EJ. Vanagt, A. P. Gorgels
  • European Journal of Clinical Pharmacology
  • 1983

Antifibrillatory efficacy of en - cainide , lorcainide and Org 6001 compared with lignocaine in isolated hearts of rabbits and guinea - pigs

  • K. Amery.W., U. P. Heykants, R. Xhonneux, G. Towse, P. Oettel, A. Gough.D.
  • British Journal of Pharmacology
  • 1981

Disposition and clinical efficiency oflorcainide ( R 15889 ) . Abstracts of papers presented at meeting held in Sydney , 13 - 15 September . 1978

  • P. M. Muller-Seydlitz, U. Klotz., G. Baumgardt., P. Heimburg
  • The efficacy and safety oflorcainide in the…
  • 1981

Similar Papers

Loading similar papers…