Lorcainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy.

@article{Eiriksson1984LorcainideAP,
  title={Lorcainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy.},
  author={C e Eiriksson and Rex N. Brogden},
  journal={Drugs},
  year={1984},
  volume={27 4},
  pages={
          279-300
        }
}
Lorcainide is a type I antiarrhythmic drug of the local anesthetic type. It can be given either intravenously or orally, and its pharmacokinetic properties allow relatively long (12 hours) dosing intervals with oral administration. A slowly eliminated metabolite, norlorcainide, probably contributes to the effects of orally administered lorcainide in chronically treated patients. In mainly short term studies, lorcainide has been shown to suppress ventricular ectopy in about 80% of patients… CONTINUE READING

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