Lorcainide disposition kinetics in arrhythmia patients

@article{Kates1983LorcainideDK,
  title={Lorcainide disposition kinetics in arrhythmia patients},
  author={R. Kates and D. Keefe and R. Winkle},
  journal={Clinical Pharmacology & Therapeutics},
  year={1983},
  volume={33}
}
  • R. Kates, D. Keefe, R. Winkle
  • Published 1983
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • Lorcainide disposition kinetics were studied after intravenous and oral administration to patients with ventricular arrhythmias. After intravenous doses ranging from 100 to 200 mg, blood samples were drawn and plasma was analyzed for lorcainide concentration by high‐pressure liquid chromatography. A three‐compartment model was used to fit the data. The model‐independent calculated values for clearance, steady‐state volume of distribution, and terminal half‐life were 14.4 ± 3.28 ml/min/kg, 6.33… CONTINUE READING
    26 Citations
    Antiarrhythmic Effect of Lorcainide in Patients Taking Digoxin

    References

    SHOWING 1-10 OF 11 REFERENCES
    Lorcainide; II. Plasma concentration‐effect relationship
    • 60
    Lorcainide; I. Saturable presystemic elimination
    • 57
    Disposition and antiarrhythmic effect of lorcainide.
    • 29
    A randomized double - blind crossover trial of lorcainide for suppression of symptomatic ventricular arrhythmias
    • Am Heart J
    • 1982
    Treatment of resistant ventricular arrhythmias by lorcainide , a new antiarrhythmic drug
    • Am J Cardiol
    • 1981
    Noncompartmental determination of the steady-state volume of distribution.
    • 795
    Saturable presystemic elimination
    • CLINT PHARce MACOL THER
    • 1979