Lorazepam solubility in and sorption from intravenous admixture solutions.

  title={Lorazepam solubility in and sorption from intravenous admixture solutions.},
  author={David W Newton and Warren A Narducci and W A Leet and Clarence T. Ueda},
  journal={American journal of hospital pharmacy},
  volume={40 3},
The solubility of lorazepam in aqueous i.v. solutions and the potential for lorazepam sorption from i.v. admixtures in flexible polyvinyl chloride (PVC) bags and tubing were determined. The solubility of triplicate samples containing 15 mg of lorazepam and 20 ml of deionized water, 5% dextrose, lactated Ringer's, or 0.9% sodium chloride injections was determined. The decrease in lorazepam concentration from a 40-micrograms/ml admixture solution in 5% dextrose injection stored in PVC bags was… CONTINUE READING

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