Lorazepam reinstates punishment-suppressed remifentanil self-administration in rats

@article{Panlilio2004LorazepamRP,
  title={Lorazepam reinstates punishment-suppressed remifentanil self-administration in rats},
  author={Leigh V. Panlilio and Eric B. Thorndike and Charles W. Schindler},
  journal={Psychopharmacology},
  year={2004},
  volume={179},
  pages={374-382}
}
We recently described a reinstatement procedure that models relapse to drug abuse in cases where abstinence results from aversive consequences of drug use. The potential value of this punishment-based model of relapse depends on its sensitivity to relapse-inducing events that are ineffective in the widely used extinction-based model. It is known that certain drugs can have antipunishment effects, but these drugs have not been tested in the punishment-based reinstatement procedure. Therefore… CONTINUE READING
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