Lorazepam analysis using liquid chromatography: improved sensitivity for single-dose pharmacokinetic studies.


Analytical methodology for lorazepam in body fluids has been hampered by the extremely high sensitivity required for detection of the low plasma lorazepam concentrations achieved after usual therapeutic dose as well as by thermal instability of the 3-hydroxybenzodiazepine ring, making gas chromatographic methods difficult to standardize. High-performance… (More)


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