Lorazepam—Efficacy, side effects, and rebound phenomena

@article{Scharf1982LorazepamEfficacySE,
  title={Lorazepam—Efficacy, side effects, and rebound phenomena},
  author={Martin B. Scharf and Judith A. Jacoby},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1982},
  volume={31}
}
  • M. ScharfJ. Jacoby
  • Published 1 February 1982
  • Psychology, Medicine
  • Clinical Pharmacology & Therapeutics
Lorazepam, 4 mg, was evaluated in an 18‐night sleep‐laboratory study involving five insomniac subjects. Hypnotic effectiveness and effects on sleep stages and related parameters were assessed. Placebo was given on baseline nights 1 to 4, lorazepam on nights 5 to 11, and placebo was given again on withdrawal nights 12 to 18. Subjective and objective data clearly demonstrated that lorazepam was effective for both inducing and maintaining sleep. Sleep latency was reduced from a baseline value of… 

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References

SHOWING 1-10 OF 10 REFERENCES

Anxiety and sleep after fosazepam.

Fosazepam administration improved subjective sleep quality, sleep was less broken, slow wave sleep stages 3 and 4 diminished in duration and so did REM sleep, suggesting action of a long half-life metabolite.

Hypnotic efficacy of lorazepam and flurazepam

In a double‐blind crossover study involving 15 insomniac subjects, the hypnotic efficacy of lorazepam, 2 and 4 mg, was compared with flurazepam, 15 and 30 mg, and placebo. Five subjective measures

Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines.

Rebound insomnia occurred following withdrawal of triazolam, nitrazepam, and flunitsepam after they had been given in only single, nightly doses for short periods, attributed to the short and intermediate half-lives of these drugs.

Lorazepam versus Glutethimide as a Sleep‐Inducing Agent for the Geriatric Patient

ABSTRACT: The safety of lorazepam was compared with that of a standard drug, glutethimide, in 50 chronically ill geriatric patients. Repeated physical examinations, laboratory determinations and

A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.

Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.

Comparative metabolism of lorazepam in man and four animal species.

The urinary route of excretion predominates in man, dog, cat, rat and miniature swine while in the rat the bulk of the drug-related material is eliminated with the feces as a consequence of biliary excretion.

Benzodiazepines in Clinical Practice

This ebooks is under topic such as guidelines for the use of benzodiazepines in office safe & effective use ofBenzodiazepine in clinical practice management of benzdiazepinesin medication-assisted treatment clinical practice guide lines for management of Benzodiazepin dependence prescribing and tapering clinical practice.

Rebound insomnia: a new clinical syndrome.

Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of

Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam.

Biotransformation to a pharmacologically inactive glucuronide metabolite appeared to be the major mechanism of lorazepam clearance and its metabolites in body fluids were determined by appropriate analytic techniques.

Multiple Comparisons among Means

Abstract Methods for constructing simultaneous confidence intervals for all possible linear contrasts among several means of normally distributed variables have been given by Scheffe and Tukey. In