Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation

@article{Kay1999LoratadineAN,
  title={Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation},
  author={G. Kay and Alan G. Harris},
  journal={Clinical \& Experimental Allergy},
  year={1999},
  volume={29}
}
  • G. Kay, A. Harris
  • Published 1 July 1999
  • Psychology
  • Clinical & Experimental Allergy
Although equally potent at blocking the H1 receptor, first‐ and second‐generation antihistamines can be distinguished with respect to their different effects on the central nervous system (CNS). First‐generation antihistamines readily cross the blood–brain barrier leading to significant drowsiness, altered mood, reduced wakefulness, and impaired cognitive and psychomotor performance. This paper reviews of studies CNS functioning conducted with loratadine, a second‐generation H1‐receptor… 
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  • 2003
The H 1 -Receptor Antagonist dextro-Chlorpheniramine Impairs Selective Auditory Attention in the Absence of Subjective Awareness of This Impairment
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The auditory selective attention is impaired under the effects of chlorpheniramine, as reflected by an attenuation of PN amplitude and by a decrease of performance in the group of subjects who took a single 4-mg dose of dextro-chlorpheniramines.
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