Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation
@article{Kay1999LoratadineAN, title={Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation}, author={G. Kay and Alan G. Harris}, journal={Clinical \& Experimental Allergy}, year={1999}, volume={29} }
Although equally potent at blocking the H1 receptor, first‐ and second‐generation antihistamines can be distinguished with respect to their different effects on the central nervous system (CNS). First‐generation antihistamines readily cross the blood–brain barrier leading to significant drowsiness, altered mood, reduced wakefulness, and impaired cognitive and psychomotor performance. This paper reviews of studies CNS functioning conducted with loratadine, a second‐generation H1‐receptor…
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