Lopinavir co-induces insulin resistance and ER stress in human adipocytes.

Abstract

HIV-protease inhibitors (PIs) markedly decreased mortality of HIV-infected patients. However, their use has been associated with occurence of metabolic abnormalities the causes of which are not well understood. We report here that lopinavir, one of the most prescribed PI, dose-dependently co-induced insulin resistance and ER stress in human adipocytes… (More)
DOI: 10.1016/j.bbrc.2009.05.148

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