Loperamide-induced enhancement of moxidectin availability in cattle.

  title={Loperamide-induced enhancement of moxidectin availability in cattle.},
  author={Adri{\'a}n Luis Lifschitz and Guillermo L Virkel and Juan Manuel Sallovitz and Fernanda A Imperiale and Alejandra Pis and Carlos E. Lanusse},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={25 2},
Moxidectin (MXD) is a milbemycin endectocide compound active at extremely low dosages against a wide variety of nematode and arthropod parasites. Different pharmacological approaches are currently being tested to delay the bile-faecal elimination and to obtain increased systemic availability for endectocide molecules in ruminants. Loperamide (LPM) is an opioid derivative, whose main pharmacological action is to abolish intestinal propulsive peristaltic waves. The influence of LPM on the pattern… CONTINUE READING