Loose coupling between Ca2+ channels and release sensors at a plastic hippocampal synapse.


The distance between Ca(2+) channels and release sensors determines the speed and efficacy of synaptic transmission. Tight "nanodomain" channel-sensor coupling initiates transmitter release at synapses in the mature brain, whereas loose "microdomain" coupling appears restricted to early developmental stages. To probe the coupling configuration at a plastic… (More)
DOI: 10.1126/science.1244811


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