Loops, linkages, rings, catenanes, cages, and crowders: entropy-based strategies for stabilizing proteins.

@article{Zhou2004LoopsLR,
  title={Loops, linkages, rings, catenanes, cages, and crowders: entropy-based strategies for stabilizing proteins.},
  author={Huan-Xiang Zhou},
  journal={Accounts of chemical research},
  year={2004},
  volume={37 2},
  pages={123-30}
}
A protein molecule exists in either a compact folded state or a variable and open unfolded state. Since the unfolded state is favored by chain entropy, restricting its entropy is an attractive mechanism for shifting the equilibrium toward the folded state. A number of entropy-based strategies have been engineered or used by natural proteins to increase the… CONTINUE READING