Loop residues of the receptor binding domain of Bacillus thuringiensis Cry11Ba toxin are important for mosquitocidal activity.


Using a Cry11Ba toxin model, predicted loops in domain II were analyzed for their role in receptor binding and toxicity. Peptides corresponding to loops alpha8, 1 and 3, but not loop 2, competed with toxin binding to Aedes midgut membranes. Mutagenesis data reveal loops alpha8, 1 and 3 are involved in toxicity. Loops 1 and 3 are of greater significance in… (More)
DOI: 10.1016/j.febslet.2009.05.020


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