Loop nucleotides control primary and mature miRNA function in target recognition and repression.

@article{Yue2011LoopNC,
  title={Loop nucleotides control primary and mature miRNA function in target recognition and repression.},
  author={Si-biao Yue and Robin Deis Trujillo and Yujie Tang and William E O'Gorman and Chang-Zheng Chen},
  journal={RNA biology},
  year={2011},
  volume={8 6},
  pages={1115-23}
}
MicroRNA (miRNA) genes produce three major RNA products; primary (pri-), precursor (pre-), and mature miRNAs. Each product includes sequences complementary to cognate targets, thus they all can in principle interact with the targets. In a recent study we showed that pri-miRNAs play a direct role in target recognition and repression in the absence of functional mature miRNAs. Here we examined the functional contribution of pri-miRNAs in target regulation when full-length functional miRNAs are… CONTINUE READING

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Our results demonstrate that the regulatory information encoded in the pri-/pre - miRNA loop nucleotides controls the activities of pri - miRNAs and mature let-7 by influencing pri - miRNA and target complex formation and the fidelity of mature miRNA seed generation .
Our results demonstrate that the regulatory information encoded in the pri-/pre - miRNA loop nucleotides controls the activities of pri - miRNAs and mature let-7 by influencing pri - miRNA and target complex formation and the fidelity of mature miRNA seed generation .
Our results demonstrate that the regulatory information encoded in the pri-/pre - miRNA loop nucleotides controls the activities of pri - miRNAs and mature let-7 by influencing pri - miRNA and target complex formation and the fidelity of mature miRNA seed generation .
Our results demonstrate that the regulatory information encoded in the pri-/pre - miRNA loop nucleotides controls the activities of pri - miRNAs and mature let-7 by influencing pri - miRNA and target complex formation and the fidelity of mature miRNA seed generation .
We found that pri - let-7 loop nucleotides control the production of the 5 ' end of mature miRNAs and modulate the activity of the miRNA gene .
We found that pri - let-7 loop nucleotides control the production of the 5 ' end of mature miRNAs and modulate the activity of the miRNA gene .
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