Loop-mediated isothermal amplification compared to real-time PCR and enzyme immunoassay for toxigenic Clostridium difficile detection.

@article{Boyanton2012LoopmediatedIA,
  title={Loop-mediated isothermal amplification compared to real-time PCR and enzyme immunoassay for toxigenic Clostridium difficile detection.},
  author={Bobby L. Boyanton and Preethi Sural and Caroline R. Loomis and Christine Pesta and Laura A Gonzalez-Krellwitz and Barbara Robinson-Dunn and Paul Riska},
  journal={Journal of clinical microbiology},
  year={2012},
  volume={50 3},
  pages={
          640-5
        }
}
Clostridium difficile infection is the primary cause of health care-associated diarrhea. While most laboratories have been using rapid antigen tests for detecting C. difficile toxins, they have poor sensitivity; newer molecular methods offer rapid results with high test sensitivity and specificity. This study was designed to compare the performances of two molecular assays (Meridian illumigene and BD GeneOhm) and two antigen assays (Wampole Quik Chek Complete and TechLab Tox A/B II) to detect… CONTINUE READING

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