Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety

  title={Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety},
  author={A. D. Krystal and Janice C Sutherland and Daryl W. Hochman},
  booktitle={PloS one},
A number of antiepileptic medications that modulate GABA(A) mediated synaptic transmission are anxiolytic. The loop diuretics furosemide (Lasix) and bumetanide (Bumex) are thought to have antiepileptic properties. These drugs also modulate GABA(A) mediated signalling through their antagonism of cation-chloride cotransporters. Given that loop diuretics may act as antiepileptic drugs that modulate GABAergic signalling, we sought to investigate whether they also mediate anxiolytic effects. Here we… CONTINUE READING


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