Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety

@inproceedings{Krystal2012LoopDH,
  title={Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety},
  author={A. D. Krystal and Janice C Sutherland and Daryl W. Hochman},
  booktitle={PloS one},
  year={2012}
}
A number of antiepileptic medications that modulate GABA(A) mediated synaptic transmission are anxiolytic. The loop diuretics furosemide (Lasix) and bumetanide (Bumex) are thought to have antiepileptic properties. These drugs also modulate GABA(A) mediated signalling through their antagonism of cation-chloride cotransporters. Given that loop diuretics may act as antiepileptic drugs that modulate GABAergic signalling, we sought to investigate whether they also mediate anxiolytic effects. Here we… CONTINUE READING

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View 7 Excerpts
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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Sodium-potassium-chloride cotransport.

Physiological reviews • 2000
View 10 Excerpts
Highly Influenced

The pharmacologic treatment of anxiety disorders: a review of progress.

The Journal of clinical psychiatry • 2010
View 3 Excerpts
Highly Influenced

An approach to the patient with anxiety

D Hicks, J ThomasCummings, SA Epstein
The Medical Clinics of North America • 2010

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