Looking within the zebrafish to understand the tuberculous granuloma.

  title={Looking within the zebrafish to understand the tuberculous granuloma.},
  author={L. Ramakrishnan},
  journal={Advances in experimental medicine and biology},
Tuberculosis is characterized by the formation of complex immune cell aggregates called granulomas, which for nearly a century have been viewed as critical host-beneficial structures to restrict bacterial growth and spread. A different view has now emerged from real-time visualization of granuloma formation and its consequences in the optically transparent and genetically tractable zebrafish larva. Pathogenic mycobacteria have developed mechanisms to use host granulomas for their expansion and… CONTINUE READING
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