Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.

@article{Booij2013LookingBT,
  title={Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.},
  author={Linda Booij and Dongsha Wang and M{\'e}lissa Luce L{\'e}vesque and Richard E. Tremblay and Moshe Szyf},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2013},
  volume={368 1615},
  pages={20120251}
}
The functioning of the hypothalamic-pituitary-adrenal (HPA) axis and serotonergic (5-HT) system are known to be intertwined with mood. Alterations in these systems are often associated with depression. However, neither are sufficient to cause depression in and of themselves. It is now becoming increasingly clear that the environment plays a crucial role, particularly, the perinatal environment. In this review, we posit that early environmental stress triggers a series of epigenetic mechanisms… CONTINUE READING