Looking beyond development: maintaining nervous system architecture.

  title={Looking beyond development: maintaining nervous system architecture.},
  author={Claire Y. B{\'e}nard and Oliver Hobert},
  journal={Current topics in developmental biology},
Neuronal circuitries established in development must persist throughout life. This poses a serious challenge to the structural integrity of an embryonically patterned nervous system as an animal dramatically increases its size postnatally, remodels parts of its anatomy, and incorporates new neurons. In addition, body movements, injury, and ageing generate physical stress on the nervous system. Specific molecular pathways maintain intrinsic properties of neurons in the mature nervous system… CONTINUE READING


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