Looking below the surface of nicotinic acetylcholine receptors.

  title={Looking below the surface of nicotinic acetylcholine receptors.},
  author={Clare Stokes and Millet Treinin and Roger L Papke},
  journal={Trends in pharmacological sciences},
  volume={36 8},
The amino acid sequences of nicotinic acetylcholine receptors (nAChRs) from diverse species can be compared across extracellular, transmembrane, and intracellular domains. The intracellular domains are most divergent among subtypes, yet relatively consistent among species. The diversity indicates that each nAChR subtype has a unique language for communication with its host cell. The conservation across species also suggests that the intracellular domains have defining functional roles for each… CONTINUE READING
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