Looking Inside Adenovirus

@article{Harrison2010LookingIA,
  title={Looking Inside Adenovirus},
  author={Stephen C. Harrison},
  journal={Science},
  year={2010},
  volume={329},
  pages={1026 - 1027}
}
Vaccines and gene therapy vectors could benefit from new insights into structure. Adenoviruses are a large group of DNA viruses with a distinguished experimental history, including contributions to the discovery of RNA splicing and the elucidation of central pathways in cell transformation (1). Some adenoviruses are human pathogens. They are also very much in vogue as potential vaccine and gene therapy vectors. Structure-based redesign of their cell-targeting and antigenic properties is… 
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29 Citations
Highly Influential Citations
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29 Citations

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The results indicate that virus infected cells do not actually show any increase in sensitivity to shear, and may indeed become less shear sensitive, in a similar manner to that previously observed in old or dead cell cultures.
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