Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

@article{Bufalo1996LonidamineIA,
  title={Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.},
  author={Donatella del Bufalo and Annamaria Biroccio and Silvia Soddu and Nina Laudonio and Carmen D'Angelo and Angelina Sacchi and Gabriella Zupi},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 5},
  pages={1165-73}
}
Lonidamine, a dichlorinated derivative of indazole-3-carboxylic acid, was shown to play a significant role in reversing or overcoming multidrug resistance. Here, we show that exposure to 50 microg/ml of lonidamine induces apoptosis in adriamycin and nitrosourea-resistant cells (MCF-7 ADR(r) human breast cancer cell line, and LB9 glioblastoma multiform cell line), as demonstrated by sub-G1 peaks in DNA content histograms, condensation of nuclear chromatin, and internucleosomal DNA fragmentation… CONTINUE READING