Lonidamine as a modulator of alkylating agent activity in vitro and in vivo.

Abstract

We are searching for relatively nontoxic compounds that can positively modulate the efficacy of antitumor alkylating agents. Lonidamine inhibits cellular energy metabolism and could potentially increase damage by alkylating agents if cellular defenses are energy requiring. Exposure of cells to lonidamine (500 microM) for 2 h under hypoxic conditions… (More)

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@article{Teicher1991LonidamineAA, title={Lonidamine as a modulator of alkylating agent activity in vitro and in vivo.}, author={Beverly A Teicher and Terrence S Herman and Sylvia A. Holden and Ronnie Epelbaum and S D Liu and Emil Frei}, journal={Cancer research}, year={1991}, volume={51 3}, pages={780-4} }