Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.

@article{Bagga2006LongtermEO,
  title={Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.},
  author={Hanish Bagga and Daniel Burkhardt and Philip N. Sambrook and Lynette M March},
  journal={The Journal of rheumatology},
  year={2006},
  volume={33 5},
  pages={946-50}
}
OBJECTIVE Intraarticular (IA) hylan injections constitute second-line therapy for osteoarthritis (OA) of the knee, but human studies suggesting a possible mechanism of action are lacking. We examined the effect of IA Hylan GF-20 injections on synovial fluid (SF) hyaluronan (HA) concentration, viscosity, and elasticity over a 6-month period in patients with mild to moderate OA of the knees. METHODS Patients with symptomatic knee OA (Osteoarthritis Research Society International grade 1-2) had… CONTINUE READING

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