Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy

@article{Kerlan1994LongitudinalSO,
  title={Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy},
  author={V{\'e}ronique Kerlan and Khalil Nahoul and Marie‐Th{\'e}r{\`e}se Martelot and Jean Pierre Bercovici},
  journal={Clinical Endocrinology},
  year={1994},
  volume={40}
}
OBJECTIVE The aim of this study to evaluate during normal pregnancy plasma bioavailable testosterone and androstanediol glucuronide levels. 
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References

SHOWING 1-10 OF 29 REFERENCES
PLASMA ANDROSTANEDIOL GLUCURONIDE LEVELS DURING PREGNANCY
TLDR
The decrease in maternal 5α‐androstane‐3α, 17β‐diol glucuronide (ADG) plasma levels from the 10th week of pregnancy parallels the decrease in dehydroepiandrosterone sulphate (DHEA‐S) concentration, which is a major precursor of ADG.
Increased maternal serum 3α, 17β-androstanediol glucuronide concentrations during pregnancy
3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.
TLDR
3 alpha-diol glucuronide is a marker of peripheral androgen action and markedly elevated in IH, and concludes that DHT is the important androgen in skin and formation of DHT and 3 alpha-Diol is markedly increased in vitro in Ih.
Testosterone, androstenedione and dehydroepiandrosterone in plasma during pregnancy and at delivery: concentration and protein binding.
TLDR
Pregnancy produces a significant increase in the concentration of testosterone in plasma, and at delivery, the plasma concentrations of Δ and D were significantly higher than those during pregnancy, while the plasma concentration of T was similar.
Total and free testosterone during pregnancy.
Precursors of plasma androstanediol- and androgen-glucuronides in women.
MATERNAL SERUM LEVELS OF SEX STEROID‐BINDING PROTEIN DURING PREGNANCY
TLDR
Six abnormal pregnancies were encountered in the present study, and in five of them the molar ratios of bound hormone to SBP concentration were much lower than the normal value, suggesting a reduced binding capacity of the protein for the hormone.
Comparison of saliva and plasma 17-hydroxyprogesterone time-course response to hCG administration in normal men.
Plasma androgens and sex hormone-binding globulin in the evaluation of hirsute females.
Testosterone and dihydrotestosterone in maternal and cord blood and in amniotic fluid.
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