Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy

@article{Kerlan1994LongitudinalSO,
  title={Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy},
  author={V{\'e}ronique Kerlan and Khalil Nahoul and Marie‐Th{\'e}r{\`e}se Martelot and Jean Pierre Bercovici},
  journal={Clinical Endocrinology},
  year={1994},
  volume={40}
}
OBJECTIVE The aim of this study to evaluate during normal pregnancy plasma bioavailable testosterone and androstanediol glucuronide levels. 
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References

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TLDR
The decrease in maternal 5α‐androstane‐3α, 17β‐diol glucuronide (ADG) plasma levels from the 10th week of pregnancy parallels the decrease in dehydroepiandrosterone sulphate (DHEA‐S) concentration, which is a major precursor of ADG.
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TLDR
3 alpha-diol glucuronide is a marker of peripheral androgen action and markedly elevated in IH, and concludes that DHT is the important androgen in skin and formation of DHT and 3 alpha-Diol is markedly increased in vitro in Ih.
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TLDR
Pregnancy produces a significant increase in the concentration of testosterone in plasma, and at delivery, the plasma concentrations of Δ and D were significantly higher than those during pregnancy, while the plasma concentration of T was similar.
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TLDR
Six abnormal pregnancies were encountered in the present study, and in five of them the molar ratios of bound hormone to SBP concentration were much lower than the normal value, suggesting a reduced binding capacity of the protein for the hormone.
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