Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults

  title={Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults},
  author={Alexandra H. Bartlett and Jane W Liang and Jose Vladimir Sandoval-Sierra and Jay H. Fowke and Eleanor M. Simonsick and Karen C Johnson and Khyobeni Mozhui},
  journal={Biomarker Research},
BackgroundChanges in DNA methylation over the course of life may provide an indicator of risk for cancer. We explored longitudinal changes in CpG methylation from blood leukocytes, and likelihood of future cancer diagnosis.MethodsPeripheral blood samples were obtained at baseline and at follow-up visit from 20 participants in the Health, Aging and Body Composition prospective cohort study. Genome-wide CpG methylation was assayed using the Illumina Infinium Human MethylationEPIC (HM850K… 
6 Citations
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