Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait.


BACKGROUND Individuals may be homozygous (SS) or heterozygous (AS) sickle cell gene carriers or have normal adult haemoglobin (AA). Haemoglobin S could have a protective role against malaria but evidence is sparse and the operating mechanisms are poorly known. METHODS We followed two cohorts of children. The first was enrolled at birth (156 newborn babies… (More)


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