Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers

@inproceedings{Olm2018LongitudinalSG,
  title={Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers},
  author={Christopher Olm and Corey T McMillan and David J Irwin and Vivianna M Van Deerlin and Philip A. Cook and James C. Gee and Murray Grossman},
  booktitle={NeuroImage: Clinical},
  year={2018}
}
Introduction Mutations in the progranulin (GRN) gene are a major source of inherited frontotemporal degeneration (FTD) spectrum disorders associated with TDP-43 proteinopathy. We use structural MRI to identify regions of baseline differences and longitudinal changes in gray matter (GM) and white matter (WM) in presymptomatic GRN mutation carriers (pGRN+) compared to young controls (yCTL). Methods Cognitively intact first-degree relatives of symptomatic GRN+ FTD patients with identified GRN… CONTINUE READING
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