Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration.


BACKGROUND Cross-sectional imaging studies offer valuable pathological insights into the neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently require sensitive monitoring markers that can detect subtle progressive changes over relatively short periods of time. We have conducted a three time-point longitudinal study… (More)
DOI: 10.1080/21678421.2017.1407795


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