Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.


In humans, mutations of amyloid precursor protein (APP) and presenilins (PS) 1 and 2 are associated with amyloid deposition, brain structural change and cognitive decline, like in Alzheimer's disease (AD). Mice expressing these proteins have illuminated neurodegenerative disease processes but, unlike in humans, quantitative imaging has been little used to… (More)
DOI: 10.1016/j.brainres.2009.02.045


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