Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy.

@article{Leung2008LongitudinalPO,
  title={Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy.},
  author={Christopher Kai-shun Leung and James Lindsey and Jonathan Guy Crowston and Chen Lijia and Sylvia W. Y. Chiang and Robert N. Weinreb},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 11},
  pages={4898-902}
}
PURPOSE To investigate the long-term longitudinal profile of retinal ganglion cell (RGC) damage after optic nerve crush with a new technique for in vivo imaging of RGCs. METHODS A blue-light confocal scanning laser ophthalmoscope (bCSLO; 460 nm excitation, 490 nm detection) was used to image Thy-1 CFP mice aged 6 to 9 months (n = 5) before optic nerve crush, weekly after crush for 3 weeks, and at weeks 10 and 50 after optic nerve crush. A sham procedure was performed in the contralateral eye… CONTINUE READING

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