Longitudinal pathologic study of the gastrocnemius muscle group in mdx mice

@article{Roig2003LongitudinalPS,
  title={Longitudinal pathologic study of the gastrocnemius muscle group in mdx mice},
  author={Manuel Valls Roig and Josep Roma and Arnau Fargas and Francina Munell},
  journal={Acta Neuropathologica},
  year={2003},
  volume={107},
  pages={27-34}
}
Muscle necrosis in mdx mice is rare before the 2nd week of life, but becomes pronounced from weeks 2 to 6. There is no agreement on what happens after this age. Using sequential microscopic histology, immunohistochemistry and histomorphometry, we studied the evolution of muscle pathology throughout the mdx life span. Between 2 weeks and 3 months, multiple necrotic groups involving variable numbers of fibres were observed in the same section. During this period, most necrotic groups comprised… CONTINUE READING
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