Longitudinal non-invasive proton NMR spectroscopy measurement of vitreous lactate in a rabbit model of ocular hypertension.

  title={Longitudinal non-invasive proton NMR spectroscopy measurement of vitreous lactate in a rabbit model of ocular hypertension.},
  author={Q. Ngumah and S. Buchthal and R. Dacheux},
  journal={Experimental eye research},
  volume={83 2},
  • Q. Ngumah, S. Buchthal, R. Dacheux
  • Published 2006
  • Chemistry, Medicine
  • Experimental eye research
  • To determine whether vitreous lactate concentrations are correlated with intraocular pressure (IOP) rise, retinal ganglion cell (RGC) damage, and nerve fiber layer (NFL) thickness decrease in a rabbit model of ocular hypertension. Also, to learn whether proton nuclear magnetic resonance ((1)H-NMR) spectroscopy can provide sequential, non-invasive in vivo measurements of vitreous lactate. Intra-anterior chamber injections of 20-mum latex beads were used to impede aqueous drainage in New Zealand… CONTINUE READING
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    Experimental glaucoma in the primate induced by latex microspheres
    • 79
    Intraocular dynamics of lactic acid in the rabbit.
    • M. Riley
    • Chemistry, Medicine
    • Investigative ophthalmology
    • 1972
    • 14
    • PDF
    Comparison of three tonometers for measuring intraocular pressure in rabbits.
    • 55
    The physiology and pathophysiology of intraocular fluids.
    • L. Bito
    • Biology, Medicine
    • Experimental eye research
    • 1977
    • 51
    Measurement of rabbit intraocular pressure with the Tono-Pen.
    • 17
    Tono-Pen XL calibration curves for cats, cows and sheep.
    • 36
    • PDF