Longitudinal interferon-β effects in multiple sclerosis: differential regulation of IL-10 and IL-17A, while no sustained effects on IFN-γ, IL-4 or IL-13.

Abstract

BACKGROUND Recent studies in experimental models and in vitro indicate lowering of IL-17/Th17 as an important mechanism of interferon-beta (IFN-β) treatment in multiple sclerosis (MS). MATERIAL AND METHODS In this longitudinal study of MS patients (n=25), spontaneous and myelin antigen-induced secretion of IL-4, IFN-γ and IL-10 (ELISPOT), mitogen… (More)
DOI: 10.1016/j.jns.2012.12.001

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@article{Kvarnstrm2013LongitudinalIE, title={Longitudinal interferon-β effects in multiple sclerosis: differential regulation of IL-10 and IL-17A, while no sustained effects on IFN-γ, IL-4 or IL-13.}, author={Mats Kvarnstr{\"o}m and J Ydrefors and Christina Ekerfelt and Magnus Vrethem and Jan Ernerudh}, journal={Journal of the neurological sciences}, year={2013}, volume={325 1-2}, pages={79-85} }