Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autism

@article{Kumar2012LongitudinalID,
  title={Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autism},
  author={Manoj Kumar and Sungheon Kim and Stephen Pickup and Rong Chen and Harish Poptani},
  journal={Brain Research},
  year={2012},
  volume={1455},
  pages={56-67}
}
Diffusion tensor imaging (DTI) is highly sensitive in detecting brain structure and connectivity phenotypes in autism spectrum disorders (ASD). Since one of the core symptoms of ASD is reduced sociability (reduced tendency to seek social interaction), we hypothesized that DTI will be sensitive in detecting neural phenotypes that correlate with decreased sociability in mouse models. Relative to C57BL/6J (B6) mice, juvenile BALB/cJ mice show reduced sociability. We performed social approach test… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED