Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease.

  title={Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease.},
  author={Mary Y Heng and Sara J Tallaksen-Greene and Peter J Detloff and Roger L Albin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={27 34},
Several murine genetic models of Huntington's disease (HD) have been developed. Murine genetic models are crucial for identifying mechanisms of neurodegeneration in HD and for preclinical evaluation of possible therapies for HD. Longitudinal analysis of mutant phenotypes is necessary to validate models and to identify appropriate periods for analysis of early events in the pathogenesis of neurodegeneration. Here we report longitudinal characterization of the murine Hdh(CAG)150 knock-in model of… CONTINUE READING


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