Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images

@article{Zhang2010LongitudinalCO,
  title={Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images},
  author={Jiangyang Zhang and Qi Peng and Qing Li and Neda Jahanshad and Zhipeng Hou and Mali Jiang and Naoki Masuda and Douglas R. Langbehn and Michael I. Miller and Susumu Mori and Christopher A. Ross and Wenzhen Duan},
  journal={NeuroImage},
  year={2010},
  volume={49 3},
  pages={2340-51}
}
Mouse models of human diseases play crucial roles in understanding disease mechanisms and developing therapeutic measures. Huntington's disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms. In symptomatic HD, striatal volumes decline predictably with disease course. Thus, imaging based volumetric measures have been proposed as outcomes for presymptomatic as well as symptomatic clinical trials of HD. Magnetic resonance imaging of the mouse brain… CONTINUE READING