Longitudinal changes of plasma pancreatic enzymes and hormones in experimental pancreatolithiasis in dogs

  title={Longitudinal changes of plasma pancreatic enzymes and hormones in experimental pancreatolithiasis in dogs},
  author={T. Hayakawa and T. Kondo and T. Shibata and M. Kitagawa and H. Sobajima and Y. Sakai and H. Ishiguro and Y. Nakae and M. Tanikawa and S. Naruse},
  journal={Digestive Diseases and Sciences},
Plasma pancreatic enzymes and hormones were longitudinally observed after producing partial obstruction of the major pancreatic duct in dogs to study an initial state of chronic pancreatitis or pancreatolithiasis. Fasting plasma immunoreactive cationic trypsin was elevated during the first six months and then decreased in a subgroup with pancreatic opposite at the end of the 12-month period. Similar but less prominent changes were found in fasting plasma immunoreactive pancreatic polypeptide… Expand
5 Citations
Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs.
  • P. Watson
  • Medicine
  • The Journal of small animal practice
  • 2003
Four dogs which developed EPI secondary to pancreatitis had concurrent hyperadrenocorticism and was euthanased five months after presentation; the other diabetic dog died 48 months after diagnosis. Expand
Pancreatitis in dogs and cats: definitions and pathophysiology.
  • P. Watson
  • Medicine
  • The Journal of small animal practice
  • 2015
Many areas that need further study in dogs and cats are suggested, including histological and clinical definitions and current understanding of the pathophysiology and causes in small animals by comparison with the much more extensive literature in humans. Expand
Pathology in Practice. Pulmonary alveolar proteinosis.
A 2.5-year-old pregnant female Huacaya alpaca was evaluated because of a mass associated with its left shoulder region, which had doubled in size in the intervening period and was interfering with its ability to cush and ambulate. Expand
Pathology in practice. Pancreatolithiasis.


Peritoneal absorption of pancreatic enzymes in dogs
The trans peritoneal absorption of pancreatic enzymes in dogs was confirmed using intraperitoneal injection of human pancreatic juice combined with immunoassay specific to human Pancreatic enzymes. Expand
Plasma pancreatic glucagon response to blood glucose in experimental pancreatolithiasis in dogs
The data suggest that the A cell response to hypoglycaemia may be impaired earlier than that to hyperglycaemia in pancreatic diabetes secondary to pancreatolithiasis. Expand
Pancreatic endocrine function in experimental pancreatolithiasis in dogs.
Endocrine insufficiency of the pancreas observed in this experimental model was similar to that reported in human pancreatolithiasis, although the severity is less. Expand
Plasma human pancreatic polypeptide response in chronic pancreatitis
SummaryThe changes of plasma pancreatic polypeptide (PP) and the relationship between PP response and exocrine pancreatic function in chronic pancreatitis are reported. In 260 healthy controlExpand
Correlation between pancreatic polypeptide response to secretin and ERCP findings in chronic pancreatitis.
The pancreatic polypeptide response to secretin was evaluated in 32 patients categorised as having advanced, moderate, or minimal chronic pancreatitis on the basis of the degree of abnormality of the retrograde pancreatogram, and was normal in patients with minimal disease. Expand
Impaired pancreatic polypeptide release in chronic pancreatitis with steatorrhoea.
Pancreatic polypeptide response to the meal was normal in 10 patients with active coeliac disease and 12 patients with acute tropical sprue with steatorrhoea, while PP response to a test breakfast was greatly reduced in patients with chronic pancreatitis with exocrine deficiency. Expand
Pancreatic glucagon-like immunoreactivity in a pancreatectomized patient.
It is suggested that, although the extra-pancreatic 'pancreatingic' GLI in a pancreatectomized patient's plasma has immunologic similarities with pancreatic glucagon, the responses to stimulation and suppression are quite different from those in controls and the biologic activity does not appear to be that of pancreatic glucose. Expand
Ultrastructural changes in the exocrine pancreas of experimental pancreatolithiasis in dogs.
Histological changes in the pancreas at an early stage of pancreatolithiasis were observed using a canine model in which obstruction was induced by partial ligation of the major pancreatic duct.Expand
Glucose tolerance and insulin secretion in rabbits and dogs after ligation of the pancreatic ducts
In dogs, as well as in rabbits, the values of fasting blood glucose remained normal for a period of 12 months following the operation, and in dogs both the intragastric and the intravenous glucose tolerance were impaired. Expand
Can plasma human pancreatic polypeptide be used to detect diseases of the exocrine pancreas?
Because the fasting HPP level has a high degree of negative predictability and is simpler to measure than the integrated HPPlevel or the output of trypsin, it may be a useful test in patients suspected of having either chronic pancreatitis or pancreatic cancer. Expand