Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative.

@article{Carmichael2010LongitudinalCI,
  title={Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative.},
  author={Owen T. Carmichael and Christopher Schwarz and David Drucker and Evan Fletcher and Danielle Harvey and Laurel Beckett and Clifford R. Jack and Michael Weiner and Charles DeCarli},
  journal={Archives of neurology},
  year={2010},
  volume={67 11},
  pages={1370-8}
}
OBJECTIVE To evaluate relationships between magnetic resonance imaging (MRI)-based measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally, and 1-year cognitive decline using a large convenience sample in a clinical trial design with a relatively mild profile of cardiovascular risk factors. DESIGN Convenience sample in a clinical trial design. SUBJECTS A total of 804 participants in the Alzheimer Disease Neuroimaging Initiative who received MRI scans… CONTINUE READING
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