Longitudinal changes in social functioning in mildly disabled patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon β-1a: results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)

Abstract

To report longitudinal changes in and explore the influence of cognition on social functioning in mildly disabled patients with relapsing–remitting multiple sclerosis (RRMS). Italian patients (18–50 years) with RRMS and Expanded Disability Status Scale (EDSS) score ≤4.0 were assigned to interferon β-1a, 44 or 22 μg subcutaneously three times weekly, and underwent annual assessments for social functioning (Environmental Status Scale [ESS]) over 3 years. Baseline total ESS score did not differ between patients with and without cognitive impairment (P = 0.505). Total ESS score remained low (<2.0) and stable over 3 years in the whole study population, but worsened slightly when assessed by assigned treatment or treatment and baseline cognitive status (both P = 0.004), driven mostly by changes in the ‘transportation’ and ‘financial/economic status’ subscales. The strongest independent predictor of worsening ESS score was baseline EDSS score. Test–retest analyses confirmed that total ESS score and most subscales changed little over 3 years. ESS scores remained low and changed minimally over 3 years, reflecting the mild physical disability and good cognitive performance in this patient population. Determining the influence of cognitive function and treatment on longitudinal changes in social functioning requires further studies.

DOI: 10.1007/s11136-011-0021-6

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Cite this paper

@article{Patti2011LongitudinalCI, title={Longitudinal changes in social functioning in mildly disabled patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon β-1a: results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)}, author={Francesco Patti and Maria Pia Amato and Mar{\'i}a Trojano and Stefano Bastianello and Maria Rosalia Tola and Orietta Picconi and Sabina Cilia and Salvatore Cottone and Luigi M. E. Grimaldi}, journal={Quality of Life Research}, year={2011}, volume={21}, pages={1111-1121} }