Longitudinal changes in fiber tract integrity in healthy aging and mild cognitive impairment: a DTI follow-up study.

@article{Teipel2010LongitudinalCI,
  title={Longitudinal changes in fiber tract integrity in healthy aging and mild cognitive impairment: a DTI follow-up study.},
  author={Stefan J. Teipel and Thomas Meindl and Maximilian Wagner and Bram Stieltjes and Sigrid Reuter and Karl-Heinz Hauenstein and Massimo Filippi and Ulrike Ernemann and Maximilian Reiser and Harald Hampel},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={22 2},
  pages={507-22}
}
Cross-sectional studies using diffusion tensor imaging (DTI) suggest decline of the integrity of intracortically projecting fiber tracts with aging and in neurodegenerative diseases, such as Alzheimer's disease (AD). Longitudinal studies on the change of fiber tract integrity in normal and pathological aging are still rare. Here, we prospectively studied 11 healthy elderly subjects and 14 subjects with amnestic mild cognitive impairment (MCI), a clinical risk group for AD, using high-resolution… CONTINUE READING