Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: Cross-validation of BSI, SIENA and SIENAX

@article{Smith2007LongitudinalAC,
  title={Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: Cross-validation of BSI, SIENA and SIENAX},
  author={Stephen M. Smith and Anil Rao and Nicola De Stefano and Mark Jenkinson and Jonathan M. Schott and Paul M. Matthews and Nick C. Fox},
  journal={NeuroImage},
  year={2007},
  volume={36},
  pages={1200-1206}
}
Brain volume loss (atrophy) is widely used as a marker of disease progression. Atrophy has been measured with a variety of methods, some estimating atrophy rate from two temporally separated scans, and others estimating atrophy state from a single scan. Three popular tools for measuring brain atrophy are BSI and SIENA (rate) and SIENAX (state). Previous papers have shown BSI and SIENA to have similar accuracy, but no work has carefully compared both methods using the same data set. Here we… CONTINUE READING

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