Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

@article{Bjornevik2022LongitudinalAR,
  title={Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis},
  author={Kjetil Bjornevik and Marianna Cortese and Brian C. Healy and Jens Kuhle and Michaela Mina and Yumei Leng and Stephen J. Elledge and David W. Niebuhr and Ann I. Scher and Kassandra L. Munger and Alberto Ascherio},
  journal={Science},
  year={2022},
  volume={375},
  pages={296 - 301}
}
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly… 
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