Longitudinal analysis of pulmonary function in adults with sickle cell disease.

  title={Longitudinal analysis of pulmonary function in adults with sickle cell disease.},
  author={Joshua J Field and Jeffrey Glassberg and Annette Gilmore and Joanna Howard and Sameer Patankar and Yan Yan and Sally L. Davies and Michael R. DeBaun and Robert C Strunk},
  journal={American journal of hematology},
  volume={83 7},
Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population… CONTINUE READING

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