Longitudinal analysis of heart and liver iron in thalassemia major.

@article{Noetzli2008LongitudinalAO,
  title={Longitudinal analysis of heart and liver iron in thalassemia major.},
  author={Leila J Noetzli and Susan M Carson and Anne S Nord and Thomas D. Coates and John C. Wood},
  journal={Blood},
  year={2008},
  volume={112 7},
  pages={2973-8}
}
High hepatic iron concentration (HIC) is associated with cardiac iron overload. However, simultaneous measurements of heart and liver iron often demonstrate no significant linear association. We postulated that slower rates of cardiac iron accumulation and clearance could reconcile these differences. To test this hypothesis, we examined the longitudinal evolution of cardiac and liver iron in 38 thalassemia major patients, using previously validated magnetic resonance imaging (MRI) techniques… CONTINUE READING

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Magnetic resonance imaging measurement of iron overload

  • JC Wood
  • Curr Opin Hematol
  • 2007

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