Longitudinal Study of Oral Microbiome Variation in Twins

  title={Longitudinal Study of Oral Microbiome Variation in Twins},
  author={Marcelo O Freire and Ahmed Moustafa and Derek M. Harkins and Manolito G. Torralba and Yun Zhang and Pamela Margaret Leong and Richard Saffery and Michelle R Bockmann and Claire Kuelbs and Toby E Hughes and Jeffrey M. Craig and Karen E. Nelson},
  journal={Scientific Reports},
Humans are host to a multitude of microorganisms that rapidly populate the body at birth, subject to a complex interplay that is dependent on host genetics, lifestyle, and environment. The host-associated microbiome, including the oral microbiome, presents itself in a complex ecosystem important to health and disease. As the most common chronic disease globally, dental caries is induced by host-microbial dysbiosis in children and adults. Multiple biological and environmental factors are likely… 

The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine

With a better understanding of the interplay between the oral microbiome and pancreatic cancer, improved diagnostic and therapeutic approaches may be implemented to reduce healthcare disparities.

The niche-specialist and age-related oral microbial ecosystem: crosstalk with host immune cells in homeostasis

The spatial and temporal characteristics of the oral microbial ecosystem in a mouse model and its crosstalk with host immune cells in homeostasis are focused on and the niche-specialist and age-related communities, characterized based on the microbiota structure, interspecies communications, microbial functions and interactions with immune cells are addressed.

Toothbrush microbiomes feature a meeting ground for human oral and environmental microbiota

Selective pressures in the built environment may shape the dynamic mixture of human (primarily oral-associated) and environmental microbiota that encounter each other on toothbrushes that could potentially serve as a reservoir that may enable the transfer of ARGs.

Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder

Improved liver health in AUD patients after alcohol abstinence was associated with lower intestinal abundances of Candida and Malassezia, and lower serum anti-C.

Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

It is reported that human genetic differences are one explanation for a stable or recurrent oral microbiome in each individual and the potential of host miRNAs to modulate the growth of specific oral bacteria is tentatively validated.

Host-Microbial Interactions in Systemic Lupus Erythematosus and Periodontitis

Local periodontal pathogen enrichment was positively associated with high systemic inflammatory profiles, relevant to the overall health and SLE disease pathogenesis.

Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?

The potential of oral commensals, and molecules derived thereof, to induce Th17 activity and provide safer and more predictable options in adjuvant engineering to prevent emerging infectious diseases is discussed.



Genetic influences on the human oral microbiome

It is demonstrated that some aspects of the human oral microbiome are heritable and that with a relatively small sample the authors were able to identify two previously unidentified loci that may be involved.

The Relationship Between the Human Genome and Microbiome Comes into View.

The microbiome needs to be incorporated into studies that quantify interactions among genotype, environment, and the microbiome in order to predict human disease susceptibility, and to identify human genetic variants associated with microbiome phenotypes.

Supragingival Plaque Microbiome Ecology and Functional Potential in the Context of Health and Disease

Oral health has substantial economic importance, with over $100 billion spent on dental care in the United States annually. The microbiome plays a critical role in oral health, yet remains poorly

Evolution of the Oral Microbiome and Dental Caries

Identification of evolutionary factors that have influenced the oral microbiome in health and caries, and how the two states differ functionally, as opposed to compositionally, may help to reduce the current burden of caries.

The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health

The factors that impact development of the oral microbiome and explore oral markers of disease, with a focus on the early oral cavity are discussed and how oral microbiomes—at the community level—could provide improved assessment in individuals and populations at risk are discussed.

Links between environment, diet, and the hunter-gatherer microbiome

Additional observations from the Hadza microbiota and their lifestyle and environment are presented, including microbes detected on hands, water, and animal sources, how the microbiota varies with sex and age, and the shortterm effects of introducing agricultural products into the diet.

Heritability of Oral Microbial Species in Caries-Active and Caries-Free Twins

It appears that genetic and/or familial factors significantly contribute to the colonization of oral beneficial species in twins from multivariate distance matrix regression analysis.

The gut microbiome in cardio-metabolic health

An overview of the development of the gut microbiome and its compositional and functional changes in relation to cardio-metabolic disorders is provided, and an update on recent progress in how this could be exploited in microbiota-based therapeutics is given.

Biogeography and individuality shape function in the human skin metagenome

This work developed a relational analysis of bacterial, fungal and viral communities, which showed not only site specificity but also individual signatures, and identified strain-level variation of dominant species as heterogeneous and multiphyletic.