Longitudinal Magnetic Resonance Spectroscopy and T2 Measurements in a Mouse Model of Niemann-Pick Type C Disease

Abstract

Introduction Niemann-Pick Type C (NPC) disease is a rare autosomal recessive neurodegenerative disease which involves impaired transport of intracellular lipids and accumulation of unesterified cholesterol in lysosomes and late endosomes in cells throughout the body [1]. NPC disease symptoms, including progressive ataxia, developmental dystonia, and… (More)

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