Longitudinal Course of Disease in a Large Cohort of Myositis Patients With Autoantibodies Recognizing the Signal Recognition Particle.

@article{PinalFernandez2017LongitudinalCO,
  title={Longitudinal Course of Disease in a Large Cohort of Myositis Patients With Autoantibodies Recognizing the Signal Recognition Particle.},
  author={Iago Pinal-Fernandez and Cassie A-L Parks and Jessie L Werner and Jemyma Albayda and Julie J. Paik and Sonye K Danoff and Livia A. Casciola-Rosen and Lisa Christopher-Stine and Andrew Mammen},
  journal={Arthritis care & research},
  year={2017},
  volume={69 2},
  pages={263-270}
}
OBJECTIVE Patients with immune-mediated necrotizing myopathy (IMNM) often have autoantibodies recognizing the signal recognition particle (SRP) or HMG-CoA reductase (HMGCR). Here, we studied a cohort of anti-SRP patients to identify factors associated with disease severity and clinical improvement; we also compared the severity of weakness in those with anti-SRP versus anti-HMGCR autoantibodies. METHODS All anti-SRP patients in the Johns Hopkins Myositis Cohort from 2002 to 2015 were included… CONTINUE READING
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