Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?

  title={Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?},
  author={Jitka Sojkova and Lori L. Beason-Held and Yun Zhou and Yang An and Michael A. Kraut and Weigo Ye and Luigi Ferrucci and Chester A. Mathis and William E. Klunk and Dean F. Wong and Susan M. Resnick},
  journal={Journal of Nuclear Medicine},
  pages={1465 - 1471}
Although cerebral amyloid deposition may precede cognitive impairment by decades, the relationship between amyloid deposition and longitudinal change in neuronal function has not, to our knowledge, been studied. The aim of this article was to determine whether individuals without dementia with high and low amyloid burden show different patterns of longitudinal regional cerebral blood flow (rCBF) changes in the years preceding measurement of amyloid deposition. Methods: Twenty-eight participants… 

Figures and Tables from this paper

Arterial spin labeling imaging reveals widespread and Aβ-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers
  • L. Michels, G. Warnock, A. Gietl
  • Biology, Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2016
It is suggested that apolipoprotein E-genotype exerts its impact on cerebral blood flow at least partly independently from amyloid beta-deposition, suggesting that Apolipopprotein E also contributes to cerebralBlood flow changes outside the context of Alzheimer’s disease.
Changes in Brain Function Occur Years before the Onset of Cognitive Impairment
Changes in resting-state brain function in humans from the Baltimore Longitudinal Study of Aging are examined to identify early markers of brain changes that occur before the onset of cognitive impairment and to suggest a connection between early pathologic change and early changes in brain function.
Amyloid imaging with PET: methodological issues and correlative studies
  • G. Lucignani
  • Biology
    European Journal of Nuclear Medicine and Molecular Imaging
  • 2009
The histopathological hallmarks of Alzheimer’s disease are the pleated sheet aggregates of amyloid-β peptide and the τ−containing neurofibrillary tangles found in the brains of affected subjects and researchers have become particularly interested in interpreting the results obtained when these tracers are used under different experimental conditions.
Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment.
Reductions of cerebral blood flow were found in several diagnostic groups, including in precuneus, entorhinal cortex and hippocampus (dementia), inferior parietal cortex (late mild cognitive impairment and dementia), and inferior temporal cortex (early and late mild cognitive impaired and dementia).
Reference region selection and the association between the rate of amyloid accumulation over time and the baseline amyloid burden
It is suggested that SUVR relative to WM may be more robust to changes in CBF, and thus fitter for sensitive detection of amyloid accumulation in intervention studies.
CSF Biomarkers Correlate with Cerebral Blood Flow on SPECT in Healthy Elderly
The findings suggest a possible correlation between tau pathology and blood flow abnormalities in individuals without any overt cognitive symptoms and an association with AD development is possible but other explanatory mechanisms cannot be excluded.
The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease
Evidence implicates cerebral blood flow (CBF) in the pathogenesis of AD and suggests its utility as a biomarker of preclinical AD, and suggests that ASL-measured CBF may be useful for identifying candidates for future AD treatment trials, especially in the preclinical, asymptomatic phases of the disease.
Impact of cerebral blood flow and amyloid load on SUVR bias
The present findings demonstrate that bias in SUVR relative to DVR is strongly related to underlying Aβ burden and in a cohort consisting mainly of cognitively unimpaired individuals, the effect of relative CBF on bias inSUVR appears limited.
Asymmetric Cerebral Blood Flow in Patients with Mild Cognitive Impairment: Possible Relationship to Further Cognitive Deterioration
The results suggest that blood flow reductions particularly in the left medial temporal region indicate an elevated risk of further cognitive decline in MCI patients.


Imaging β-amyloid burden in aging and dementia
Pittsburgh Compound B PET findings match histopathologic reports of β-amyloid (Aβ) distribution in aging and dementia, and suggest that Aβ may influence the development of dementia with Lewy bodies, and therefore strategies to reduce A β may benefit this condition.
Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT.
SPM analysis showed the characteristic early-AD rCBF pattern of selective decrease and longitudinal decline, which may be overlooked by a conventional region-of-interest technique with observer a priori choice and hypothesis, may closely relate to the pathophysiologic process of this disease.
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
  • J. Price, W. Klunk, C. Mathis
  • Medicine, Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2005
It was shown that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum and the Logan analysis was the method-of-choice for the PIBPET data as it proved stable, valid, and promising for future larger studies and voxel-based statistical analyses.
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease.
Single photon emission computed tomography perfusion differences in mild cognitive impairment
The results suggest that clinical heterogeneity in MCI is reflected in SPECT perfusion differences, and that the pattern of perfusion abnormalities evolves with increasing clinical severity.
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy, which may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.
One-year age changes in MRI brain volumes in older adults.
Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia, in nondemented older participants in the Baltimore Longitudinal Study of Aging.
PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment
At group level the elevated N-methyl-[11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C)PIB uptake in patients with mild cognitive impairment (MCI) resembled that seen in Alzheimer disease (AD).
Neuronal Hypertrophy in Asymptomatic Alzheimer Disease
The hypertrophy of cortical neurons and their nuclei and nucleoli in ASYMAD may represent an early reaction to the presence of neurotoxic Aβ or tau, or a compensatory mechanism that prevents the progression of the disease into dementia.