Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities

@article{Olsen2012LongitudinalAO,
  title={Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities},
  author={Geary W. Olsen and David J. Ehresman and Betsy D Buehrer and Barbara Ann Gibson and John L. Butenhoff and Larry R. Zobel},
  journal={Journal of Occupational and Environmental Medicine},
  year={2012},
  volume={54},
  pages={974–983}
}
Objective: To examine in a longitudinal occupational assessment whether changes in serum concentrations of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are associated with changes in non–high-density lipoprotein (HDL) cholesterol. Methods: Baseline and end-of-project PFOA, PFOS, lipid, and hepatic clinical chemistries were measured in 204 workers involved with the demolition of former perfluoroalkyl manufacturing facilities. Analyses were restricted to the 179 workers who… 

Reductions in Serum Lipids with a 4-year Decline in Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid

Previous evidence from cross-sectional studies of positive associations between PFOA and PFOS in serum and LDL cholesterol support the findings from this longitudinal study, which is less susceptible to biases from uncontrolled confounding or reverse causality.

Association Between PFOA Exposure and Liver Enzymes: a Systematic Review and Meta-analysis of Longitudinal Cohort Studies

The hypothesis that PFOA increases levels of four common liver enzymes, and that this causal relationship was observed within the context of a population-based study area, is supported.

Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice

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References

SHOWING 1-10 OF 47 REFERENCES

Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers

The findings indicate a modest positive association of PFOA on some lipid parameters and a need for follow-up studies.

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

  • G. OlsenL. R. Zobel
  • Medicine
    International archives of occupational and environmental health
  • 2007
There was no evidence that employees’ serum PFOA concentrations were associated with total cholesterol or LDL, and several explanations are offered for the inconsistent triglyceride associations with PFO a including both methodological as well as biological possibilities.

Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project.

Associations between increasing PFOA and PFOS and elevated total cholesterol and LDL-C levels warrant further study, and the epidemiologic and cross-sectional natures of this study limit causal inferences.

Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults

It is concluded that a higher serum concentration of PFOA may cause liver enzymes to increase abnormally in the general population, particularly in obese individuals.

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Higher concentrations of serum PFOA and PFOS are associated with current thyroid disease in the U.S. general adult population and more work is needed to establish the mechanisms involved and to exclude confounding and pharmacokinetic explanations.

Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice.

The potency of PFAS to affect lipoprotein metabolism increased with increasing alkyl chain length, implying that the reported positive correlations of serum PFOS and non-HDL-C are associative rather than causal.

Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure

A positive association between PFOA and PFOS concentrations and serum ALT level, a marker of hepatocellular damage is shown, and the relationship with bilirubin appears to rise at low levels of PFO a and to fall again at higher levels.